Researchers reveal role of polyphenols in regulating inflammatory immune responses
PCB2DG, an anti-inflammatory polyphenol, inhibits glutamine absorption by targeting and directly interacting with the main glutamine transporter protein, alanine serine cysteine transporter 2 (ASCT2). This reduction in intracellular glutamine accumulation in CD4+ T cells also inhibits the production of interferon-gamma, or IFN-, indicating that dietary polyphenol therapy for autoimmune illnesses may be beneficial in the future. Furthermore, one of the study's major accomplishments was the discovery of ASCT2 as the target protein of PCB2DG, which opens up new avenues for research into the effects of dietary polyphenols on immunological responses.